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Faculties

Wenqing XU(徐文清), Ph.D, Professor 

  
Dr. XU is the director of departmemt of pharmaceutica, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College. She mainly engaged in research of radioprotector and radiosensitizer. She has extensive research expertise in natural products, medical chemistry and pharmacology.  
 
 

EDUCATION

Tianjin University, Tianjin,China
Ph.D. Pharmaceutical Sciences and Technology. Major in Applied Chemistry, 2003-2006 
Peking Union Medical College, Beijing, China
M.S.Med. Major in Medicinal Chemistry, 1999-2002 
Beijing University of Traditional Chinese Medicine, Beijing, China
B.S.Med. Major in Chinese Materia Medica, 1984-1989
 

RESEARCH  EXPERIENCE 

2012-present
 Synthesized a series of derivatives of rosmarinic acid and expolred its radioprotective effects.
 
2010-present
 Synthesized several derivatives of tanshinone, emodin and expolred its radiosensitivity.
 
2008-present
 Found out a novel prophylactic ( 2,2-dimethy-tetrahydrothiazole) in radiation protection. 
  Synthesized the compound, authenticated its chemical structure, founded the quantitative methods, evaluated its bioactivity and safety. 
 
2007-2008
Found out several compounds with different structure style from natural products and explored its radiosensitivity. 
Studied on radiosensitization of Emodin-type anthraquinone compounds. 
 
2003-2007
Extracted and separated polysaccharide from Tremella fuciformis
  Authenticated the chemical structure by using PC, GC, GC-MS and NMR technologies,   determined molecular weight distribution by HPLC 
  Evaluated its effects of anti-tumor, hematopoietic protection and immunologic enhancement in mice model.
 

MAJOR PUBLICATIONS

1. Li J, Li G, Xu W*. Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy. Curr Med Chem. 20:1858-1886, 2013. 
2. Wenqing XU*, Xiu SHEN , Fujun YANG , Ying HAN,Ruifeng LI, Dan XUE, Chengfeng JIANG. Protective effect of polysaccharides isolated from Tremella fuciformis against radiation-induced damage in mice.Journal of radiation research. 53(3):353-360, 2012
3. Yintao Ye, Wenqing Xu, Wei Zhong, Yajing Li, Chen Wang. Combination treatment with dihydrotanshinone I and irradiation enhances apoptotic effects in human cervical cancer by HPV E6 down-regulation and caspases activation. Mol Cell Biochem. 363:191-202, 2012  
 
E-mail: xuwenqing@irm-cams.ac.cn

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