Dr. XU is the director of departmemt of pharmaceutica, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College. She mainly engaged in research of radioprotector and radiosensitizer. She has extensive research expertise in natural products, medical chemistry and pharmacology.  

 

 

Tianjin University, Tianjin,China

Ph.D. Pharmaceutical Sciences and Technology. Major in Applied Chemistry, 2003-2006 

Peking Union Medical College, Beijing, China

M.S.Med. Major in Medicinal Chemistry, 1999-2002 

Beijing University of Traditional Chinese Medicine, Beijing, China

B.S.Med. Major in Chinese Materia Medica, 1984-1989

 

2012-present

 Synthesized a series of derivatives of rosmarinic acid and expolred its radioprotective effects.

 

2010-present

 Synthesized several derivatives of tanshinone, emodin and expolred its radiosensitivity.

 

2008-present

 Found out a novel prophylactic ( 2,2-dimethy-tetrahydrothiazole) in radiation protection. 

  Synthesized the compound, authenticated its chemical structure, founded the quantitative methods, evaluated its bioactivity and safety. 

 

2007-2008

Found out several compounds with different structure style from natural products and explored its radiosensitivity. 

Studied on radiosensitization of Emodin-type anthraquinone compounds. 

 

2003-2007

Extracted and separated polysaccharide from Tremella fuciformis

  Authenticated the chemical structure by using PC, GC, GC-MS and NMR technologies,   determined molecular weight distribution by HPLC 

  Evaluated its effects of anti-tumor, hematopoietic protection and immunologic enhancement in mice model.

 

1. Li J, Li G, Xu W*. Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy. Curr Med Chem. 20:1858-1886, 2013. 

2. Wenqing XU*, Xiu SHEN , Fujun YANG , Ying HAN，Ruifeng LI, Dan XUE, Chengfeng JIANG. Protective effect of polysaccharides isolated from Tremella fuciformis against radiation-induced damage in mice.Journal of radiation research. 53(3):353-360, 2012

3. Yintao Ye, Wenqing Xu, Wei Zhong, Yajing Li, Chen Wang. Combination treatment with dihydrotanshinone I and irradiation enhances apoptotic effects in human cervical cancer by HPV E6 down-regulation and caspases activation. Mol Cell Biochem. 363:191-202, 2012  

 

E-mail: xuwenqing@irm-cams.ac.cn